Optimal Design for Nonlinear Response Models
Valerii V. Fedorov, Quintiles;
Sergei L. Leonov, AstraZeneca
CRC Press, Inc., 2014
ISBN: 978-1-4398-2151-0;
Language: English
Written for graduate students and researchers, Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. While the focus is on nonlinear models, the book begins with an explanation of the key ideas, using linear models as examples. Applying the linearization in the parameter space, it then covers nonlinear models and locally optimal designs as well as minimax, optimal on average, and Bayesian designs. Topics include regression models and their analysis, convex design theory, algorithms, and numerical techniques.
MATLAB is used to solve examples in the book.
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